About Interleukin-18
Interleukin-18 (IL18) is a protein
from Homo sapiens identified by UniProt accession
Q14116, 193 residues long.
MolForge cross-references it against 0 known binders and
1,376 disease associations.
Target properties
| Protein name | Interleukin-18 |
|---|
| UniProt accession | Q14116 |
|---|
| Gene | IL18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1376)
Diseases linked to this target (Open Targets).
- interleukin 18 measurement · score 0.33
- breast adenocarcinoma · score 0.18
- adult-onset Still's disease · score 0.13
- heel bone mineral density · score 0.12
- bone quantitative ultrasound measurement · score 0.12
- neoplasm · score 0.12
- chronic obstructive pulmonary disease · score 0.12
- inflammatory bowel disease · score 0.12
- Systemic lupus erythematosus · score 0.11
- Rheumatoid arthritis · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14116-F1 | alphafold | PREDICTED | 89.01 | — |
Amino-acid sequence (193 residues)
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
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