Dihydropyrimidinase (DPYS)

About Dihydropyrimidinase

Dihydropyrimidinase (DPYS) is a protein from Homo sapiens identified by UniProt accession Q14117, 519 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Dihydropyrimidinase
UniProt accession	Q14117
Gene	DPYS
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

dihydropyrimidinuria · score 0.77
genetic disorder · score 0.41
metabolite measurement · score 0.30
3-ureidopropionate measurement · score 0.30
salivary metabolite measurement · score 0.30
Paralytic ileus · score 0.24
cutaneous melanoma · score 0.22
blood protein measurement · score 0.19
osteitis deformans · score 0.18
irritability measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14117-F1	alphafold	PREDICTED	95.82	—

Amino-acid sequence (519 residues)

MAAPSRLLIR GGRVVNDDFS EVADVLVEDG VVRALGHDLL PPGGAPAGLR VLDAAGKLVL PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID FAIPQKGGSL IEAFETWRSW ADPKVCCDYS LHVAVTWWSD QVKEEMKILV QDKGVNSFKM FMAYKDLYMV TDLELYEAFS RCKEIGAIAQ VHAENGDLIA EGAKKMLALG ITGPEGHELC RPEAVEAEAT LRAITIASAV NCPLYIVHVM SKSAAKVIAD ARRDGKVVYG EPIAASLGTD GTHYWNKEWH HAAHHVMGPP LRPDPSTPDF LMNLLANDDL TTTGTDNCTF NTCQKALGKD DFTKIPNGVN GVEDRMSVIW EKGVHSGKMD ENRFVAVTST NAAKIFNLYP RKGRIAVGSD ADIVIWDPKG TRTISAKTHH QAVNFNIFEG MVCHGVPLVT ISRGKVVYEA GVFSVTAGDG KFIPRKPFAE YIYKRIKQRD RTCTPTPVER APYKGEVATL KSRVTKEDAT AGTRKQAHP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards