Vascular endothelial zinc finger 1 (VEZF1)

About Vascular endothelial zinc finger 1

Vascular endothelial zinc finger 1 (VEZF1) is a protein from Homo sapiens identified by UniProt accession Q14119, 521 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Vascular endothelial zinc finger 1
UniProt accession	Q14119
Gene	VEZF1
Organism	Homo sapiens
Length	521 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
lysosomal storage disease · score 0.37
Parkinson disease · score 0.37
Alzheimer disease · score 0.37
multiple sclerosis · score 0.37
familial isolated dilated cardiomyopathy · score 0.37
body mass index · score 0.27
body fat percentage · score 0.21
waist circumference · score 0.15
autism spectrum disorder · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14119-F1	alphafold	PREDICTED	59.42	—

Amino-acid sequence (521 residues)

MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ QQQQHVTSWP GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP FSITSSVSSG TMSNPVTVAA AMSMRSPVNV SSAVNITSPM NIGHPVTITS PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV TITSPMNLPT PMTLAAPLNI AMRPVESMPF LPQALPTSPP W

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards