About Transcription cofactor vestigial-like protein 4
Transcription cofactor vestigial-like protein 4 (VGLL4) is a protein
from Homo sapiens identified by UniProt accession
Q14135, 290 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Transcription cofactor vestigial-like protein 4 |
|---|
| UniProt accession | Q14135 |
|---|
| Gene | VGLL4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (116)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- body height · score 0.34
- lean body mass · score 0.34
- body mass index · score 0.31
- FEV/FVC ratio · score 0.31
- appendicular lean mass · score 0.28
- birth weight · score 0.28
- fat body mass · score 0.27
- body weight · score 0.25
- sitting height measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14135-F1 | alphafold | PREDICTED | 60.98 | — |
Amino-acid sequence (290 residues)
METPLDVLSR AASLVHADDE KREAALRGEP RIQTLPVASA LSSHRTGPPP ISPSKRKFSM EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER SRSPIERAVA PTMSLHGSHL YTSLPSLGLE QPLALTKNSL DASRPAGLSP TLTPGERQQN RPSVITCASA GARNCNLSHC PIAHSGCAAP GPASYRRPPS AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH FAKALGDTWL QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS
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