SERTA domain-containing protein 2 (SERTAD2)

About SERTA domain-containing protein 2

SERTA domain-containing protein 2 (SERTAD2) is a protein from Homo sapiens identified by UniProt accession Q14140, 314 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	SERTA domain-containing protein 2
UniProt accession	Q14140
Gene	SERTAD2
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
mean corpuscular volume · score 0.51
sex hormone-binding globulin measurement · score 0.50
Red cell distribution width · score 0.49
mean corpuscular hemoglobin · score 0.48
mean corpuscular hemoglobin concentration · score 0.48
erythrocyte count · score 0.46
testosterone measurement · score 0.45
heel bone mineral density · score 0.45
platelet count · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14140-F1	alphafold	PREDICTED	59.80	—

Amino-acid sequence (314 residues)

MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD LTELDHIMEV LVGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards