About Septin-6
Septin-6 (SEPTIN6) is a protein
from Homo sapiens identified by UniProt accession
Q14141, 434 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Septin-6 |
|---|
| UniProt accession | Q14141 |
|---|
| Gene | SEPTIN6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 434 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.20
- acute myeloid leukemia · score 0.19
- non-small cell lung carcinoma · score 0.19
- pancreatic ductal adenocarcinoma · score 0.19
- pancreatic carcinoma · score 0.19
- breast carcinoma · score 0.19
- B-cell acute lymphoblastic leukemia · score 0.18
- gastric carcinoma · score 0.18
- oral squamous cell carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14141-F1 | alphafold | PREDICTED | 80.91 | — |
Amino-acid sequence (434 residues)
MAATDIARQV GEGCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE TGLGKSTLMD TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVRLKLTIV STVGFGDQIN KEDSYKPIVE FIDAQFEAYL QEELKIRRVL HTYHDSRIHV CLYFIAPTGH SLKSLDLVTM KKLDSKVNII PIIAKADAIS KSELTKFKIK ITSELVSNGV QIYQFPTDDE SVAEINGTMN AHLPFAVIGS TEELKIGNKM MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV KEKEAELKEA EKELHEKFDR LKKLHQDEKK KLEDKKKSLD DEVNAFKQRK TAAELLQSQG SQAGGSQTLK RDKEKKNNPW LCTE
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