Tripartite motif-containing protein 14 (TRIM14)

About Tripartite motif-containing protein 14

Tripartite motif-containing protein 14 (TRIM14) is a protein from Homo sapiens identified by UniProt accession Q14142, 442 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 14
UniProt accession	Q14142
Gene	TRIM14
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

spondyloepimetaphyseal dysplasia, Genevieve type · score 0.53
multiple sclerosis · score 0.29
genetic disorder · score 0.19
reticulocyte count · score 0.13
eosinophil count · score 0.11
neoplasm · score 0.10
hepatocellular carcinoma · score 0.09
breast cancer · score 0.08
gonorrhea · score 0.08
non-small cell lung carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14142-F1	alphafold	PREDICTED	85.72	—

Amino-acid sequence (442 residues)

MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL GAHRGHPVGL ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL KANAESSKTW LKGKFTELRL LLDEEEALAK KFIDKNTQLT LQVYREQADS CREQLDIMND LSNRVWSISQ EPDPVQRLQA YTATEQEMQQ QMSLGELCHP VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS DPSSTKPGTL LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS AAARLGCNRQ SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG VLAFYDVTGG MSHLHTFRAT FQEPLYPALR LWEGAISIPR LP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards