About Kelch-like ECH-associated protein 1
Kelch-like ECH-associated protein 1 (KEAP1) is a protein
from Homo sapiens identified by UniProt accession
Q14145, 624 residues long.
MolForge cross-references it against 0 known binders and
608 disease associations.
Target properties
| Protein name | Kelch-like ECH-associated protein 1 |
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| UniProt accession | Q14145 |
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| Gene | KEAP1 |
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| Organism | Homo sapiens |
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| Length | 624 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (608)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.63
- lung adenocarcinoma · score 0.62
- relapsing-remitting multiple sclerosis · score 0.59
- non-small cell lung carcinoma · score 0.55
- squamous cell lung carcinoma · score 0.53
- psoriasis · score 0.47
- immune system disease · score 0.46
- neurodegenerative disease · score 0.44
- hepatocellular carcinoma · score 0.44
- lung carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14145-F1 | alphafold | PREDICTED | 90.06 | — |
Amino-acid sequence (624 residues)
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC
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