About Unhealthy ribosome biogenesis protein 2 homolog
Unhealthy ribosome biogenesis protein 2 homolog (URB2) is a protein
from Homo sapiens identified by UniProt accession
Q14146, 1524 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Unhealthy ribosome biogenesis protein 2 homolog |
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| UniProt accession | Q14146 |
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| Gene | URB2 |
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| Organism | Homo sapiens |
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| Length | 1524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.29
- mean corpuscular hemoglobin concentration · score 0.28
- mean corpuscular hemoglobin · score 0.27
- mean reticulocyte volume · score 0.27
- erythrocyte count · score 0.24
- body height · score 0.23
- red blood cell density measurement · score 0.13
- epilepsy · score 0.12
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14146-F1 | alphafold | PREDICTED | 82.26 | — |
Amino-acid sequence (1524 residues)
MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ SLVAFYKKKL ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV KIINERVAEF SLSGSQRNIC AVLRCCQGIL STPALAVIYT AKQELMVALL SQLCWSACRQ PEGAVVAQLF EVIHLALGHY LLILQQQVNP RRAFGDVTAH LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM FRGGIFQPEL LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST SDWTTELLVV EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH AQAPIPAWFR CLKTLISLNH LILEPDLDDL LASAWIDAEV TEFRTKKAQE ALIRTVFQTY AKLRQVPRLF EEVLGVICRP AAEALRQPVL ASGPSTVLSA CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL SLSLLLHCIM FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG VKTQHWKKIE KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL RCDAAFIIGS GRKSLNQRTT ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL ISYLCPDDVG YLASVLLRTL PMGKAQEVSI DEEAYITLEK ISKAFLHSPL FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW LFEKDHMVVG HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG YLQKGKSARS VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV IGTFLEELMQ MLIQMKLSLV LNFRKITAFL SSSKPYTEAA SSKQLENQNP QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA PAALSELLQQ VVLQTGAVLQ LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS QGSDRTLLSH VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI LQGLDVSNMW KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA LTLLNREASQ EQPVSLTVVG PVLDVLAALL RQGEEAIGNP HHVSLAFSIL LTVPLDHLKP LEYGSVFPRL HNVLFSILQC HPKVMLKAIP SFLNSFNRLV FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE EFAVFSPFMV AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI FKELYNDYLK YHKAKHEGEK RYTA
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