About Probable ATP-dependent RNA helicase DHX34
Probable ATP-dependent RNA helicase DHX34 (DHX34) is a protein
from Homo sapiens identified by UniProt accession
Q14147, 1143 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DHX34 |
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| UniProt accession | Q14147 |
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| Gene | DHX34 |
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| Organism | Homo sapiens |
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| Length | 1143 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.45
- neurodegenerative disease · score 0.37
- Intellectual disability · score 0.36
- Neurodevelopmental delay · score 0.35
- Seizure · score 0.30
- Polycystic Kidney Disease · score 0.26
- Short stature · score 0.26
- emphysema · score 0.26
- Microcephaly · score 0.26
- Meckel syndrome · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14147-F1 | alphafold | PREDICTED | 80.50 | — |
Amino-acid sequence (1143 residues)
MPPPRTREGR DRRDHHRAPS EEEALEKWDW NCPETRRLLE DAFFREEDYI RQGSEECQKF WTFFERLQRF QNLKTSRKEE KDPGQPKHSI PALADLPRTY DPRYRINLSV LGPATRGSQG LGRHLPAERV AEFRRALLHY LDFGQKQAFG RLAKLQRERA ALPIAQYGNR ILQTLKEHQV VVVAGDTGCG KSTQVPQYLL AAGFSHVACT QPRRIACISL AKRVGFESLS QYGSQVGYQI RFESTRSAAT KIVFLTVGLL LRQIQREPSL PQYEVLIVDE VHERHLHNDF LLGVLQRLLP TRPDLKVILM SATINISLFS SYFSNAPVVQ VPGRLFPITV VYQPQEAEPT TSKSEKLDPR PFLRVLESID HKYPPEERGD LLVFLSGMAE ISAVLEAAQT YASHTQRWVV LPLHSALSVA DQDKVFDVAP PGVRKCILST NIAETSVTID GIRFVVDSGK VKEMSYDPQA KLQRLQEFWI SQASAEQRKG RAGRTGPGVC FRLYAESDYD AFAPYPVPEI RRVALDSLVL QMKSMSVGDP RTFPFIEPPP PASLETAILY LRDQGALDSS EALTPIGSLL AQLPVDVVIG KMLILGSMFS LVEPVLTIAA ALSVQSPFTR SAQSSPECAA ARRPLESDQG DPFTLFNVFN AWVQVKSERS RNSRKWCRRR GIEEHRLYEM ANLRRQFKEL LEDHGLLAGA QAAQVGDSYS RLQQRRERRA LHQLKRQHEE GAGRRRKVLR LQEEQDGGSS DEDRAGPAPP GASDGVDIQD VKFKLRHDLA QLQAAASSAQ DLSREQLALL KLVLGRGLYP QLAVPDAFNS SRKDSDQIFH TQAKQGAVLH PTCVFAGSPE VLHAQELEAS NCDGSRDDKD KMSSKHQLLS FVSLLETNKP YLVNCVRIPA LQSLLLFSRS LDTNGDCSRL VADGWLELQL ADSESAIRLL AASLRLRARW ESALDRQLAH QAQQQLEEEE EDTPVSPKEV ATLSKELLQF TASKIPYSLR RLTGLEVQNM YVGPQTIPAT PHLPGLFGSS TLSPHPTKGG YAVTDFLTYN CLTNDTDLYS DCLRTFWTCP HCGLHAPLTP LERIAHENTC PQAPQDGPPG AEEAALETLQ KTSVLQRPYH CEACGKDFLF TPTEVLRHRK QHV
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