About DAP3-binding cell death enhancer 1
DAP3-binding cell death enhancer 1 (DELE1) is a protein
from Homo sapiens identified by UniProt accession
Q14154, 515 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | DAP3-binding cell death enhancer 1 |
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| UniProt accession | Q14154 |
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| Gene | DELE1 |
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| Organism | Homo sapiens |
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| Length | 515 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.26
- reticulocyte measurement · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.07
- insomnia measurement · score 0.04
- acute myeloid leukemia · score 0.04
- gonadoblastoma · score 0.03
- 46,XX testicular disorder of sex development · score 0.03
- 46,XX ovotesticular disorder of sex development · score 0.03
- drug use measurement · score 0.03
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14154-F1 | alphafold | PREDICTED | 61.08 | — |
Amino-acid sequence (515 residues)
MWRLPGLLGR ALPRTLGPSL WRVTPKSTSP DGPQTTSSTL LVPVPNLDRS GPHGPGTSGG PRSHGWKDAF QWMSSRVSPN TLWDAISWGT LAVLALQLAR QIHFQASLPA GPQRVEHCSW HSPLDRFFSS PLWHPCSSLR QHILPSPDGP APRHTGLREP RLGQEEASAQ PRNFSHNSLR GARPQDPSEE GPGDFGFLHA SSSIESEAKP AQPQPTGEKE QDKSKTLSLE EAVTSIQQLF QLSVSIAFNF LGTENMKSGD HTAAFSYFQK AAARGYSKAQ YNAGLCHEHG RGTPRDISKA VLYYQLAASQ GHSLAQYRYA RCLLRDPASS WNPERQRAVS LLKQAADSGL REAQAFLGVL FTKEPYLDEQ RAVKYLWLAA NNGDSQSRYH LGICYEKGLG VQRNLGEALR CYQQSAALGN EAAQERLRAL FSMGAAAPGP SDLTVTGLKS FSSPSLCSLN TLLAGTSRLP HASSTGNLGL LCRSGHLGAS LEASSRAIPP HPYPLERSVV RLGFG
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