About Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) is a protein
from Homo sapiens identified by UniProt accession
Q14164, 716 residues long.
MolForge cross-references it against 0 known binders and
231 disease associations.
Target properties
| Protein name | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
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| UniProt accession | Q14164 |
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| Gene | IKBKE |
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| Organism | Homo sapiens |
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| Length | 716 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (231)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- neuroinflammatory disorder · score 0.37
- eosinophil count · score 0.25
- eosinophil percentage of leukocytes · score 0.22
- systemic lupus erythematosus · score 0.21
- lung adenocarcinoma · score 0.19
- psoriasis · score 0.18
- total blood protein measurement · score 0.17
- lymphocyte percentage of leukocytes · score 0.16
- blood protein measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14164-F1 | alphafold | PREDICTED | 88.57 | — |
Amino-acid sequence (716 residues)
MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTTSYLRPRE VQVREFEVLR KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE KPAGAIAGAQ RRENGPLEWS YTLPITCQLS LGLQSQLVPI LANILEVEQA KCWGFDQFFA ETSDILQRVV VHVFSLSQAV LHHIYIHAHN TIAIFQEAVH KQTSVAPRHQ EYLFEGHLCV LEPSVSAQHI AHTTASSPLT LFSTAIPKGL AFRDPALDVP KFVPKVDLQA DYNTAKGVLG AGYQALRLAR ALLDGQELMF RGLHWVMEVL QATCRRTLEV ARTSLLYLSS SLGTERFSSV AGTPEIQELK AAAELRSRLR TLAEVLSRCS QNITETQESL SSLNRELVKS RDQVHEDRSI QQIQCCLDKM NFIYKQFKKS RMRPGLGYNE EQIHKLDKVN FSHLAKRLLQ VFQEECVQKY QASLVTHGKR MRVVHETRNH LRLVGCSVAA CNTEAQGVQE SLSKLLEELS HQLLQDRAKG AQASPPPIAP YPSPTRKDLL LHMQELCEGM KLLASDLLDN NRIIERLNRV PAPPDV
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