About Tubulin--tyrosine ligase-like protein 12
Tubulin--tyrosine ligase-like protein 12 (TTLL12) is a protein
from Homo sapiens identified by UniProt accession
Q14166, 644 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Tubulin--tyrosine ligase-like protein 12 |
|---|
| UniProt accession | Q14166 |
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| Gene | TTLL12 |
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| Organism | Homo sapiens |
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| Length | 644 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- body height · score 0.39
- C-reactive protein measurement · score 0.25
- monocyte count · score 0.24
- platelet count · score 0.24
- myeloid white cell count · score 0.22
- leukocyte count · score 0.18
- neutrophil count · score 0.17
- platelet crit · score 0.17
- monocyte percentage of leukocytes · score 0.16
- basophil count · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14166-F1 | alphafold | PREDICTED | 90.99 | — |
Amino-acid sequence (644 residues)
MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG RLLHKLEHEV FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK VIVTRESGLQ AAHPNSIFLI DHAWTCRVEH ARQQLQQVPG LLHRMANLMG IEFHGELPST EAVALVLEEM WKFNQTYQLA HGTAEEKMPV WYIMDEFGSR IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR DFAYGETDPL IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE RPGVLLNQFP CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF VSYFQQRERW GEDNHWICKP WNLARSLDTH VTKSLHSIIR HRESTPKVVS KYIESPVLFL REDVGKVKFD IRYIVLLRSV RPLRLFVYDV FWLRFSNRAF ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP EFPWTDVQAE IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV
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