About MAGUK p55 subfamily member 2
MAGUK p55 subfamily member 2 (MPP2) is a protein
from Homo sapiens identified by UniProt accession
Q14168, 576 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | MAGUK p55 subfamily member 2 |
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| UniProt accession | Q14168 |
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| Gene | MPP2 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- Varicose veins · score 0.09
- X-linked retinal dysplasia · score 0.07
- age-related macular degeneration · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- muscular atrophy-ataxia-retinitis pigmentosa-diabetes mellitus syndrome · score 0.06
- choroidal dystrophy, central areolar, 1 · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- Muscular atrophy - ataxia - retinitis pigmentosa - diabetes mellitus · score 0.05
- age related macular degeneration 7 · score 0.04
- age related macular degeneration 11 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14168-F1 | alphafold | PREDICTED | 78.94 | — |
Amino-acid sequence (576 residues)
MPVAATNSET AMQQVLDNLG SLPSATGAAE LDLIFLRGIM ESPIVRSLAK VIMVLWFMQQ NVFVPMKYML KYFGAHERLE ETKLEAVRDN NLELVQEILR DLAHVAEQSS TAAELAHILQ EPHFQSLLET HDSVASKTYE TPPPSPGLDP TFSNQPVPPD AVRMVGIRKT AGEHLGVTFR VEGGELVIAR ILHGGMVAQQ GLLHVGDIIK EVNGQPVGSD PRALQELLRN ASGSVILKIL PSYQEPHLPR QVFVKCHFDY DPARDSLIPC KEAGLRFNAG DLLQIVNQDD ANWWQACHVE GGSAGLIPSQ LLEEKRKAFV KRDLELTPNS GTLCGSLSGK KKKRMMYLTT KNAEFDRHEL LIYEEVARMP PFRRKTLVLI GAQGVGRRSL KNKLIMWDPD RYGTTVPYTS RRPKDSEREG QGYSFVSRGE MEADVRAGRY LEHGEYEGNL YGTRIDSIRG VVAAGKVCVL DVNPQAVKVL RTAEFVPYVV FIEAPDFETL RAMNRAALES GISTKQLTEA DLRRTVEESS RIQRGYGHYF DLCLVNSNLE RTFRELQTAM EKLRTEPQWV PVSWVY
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