About DNA polymerase alpha subunit B
DNA polymerase alpha subunit B (POLA2) is a protein
from Homo sapiens identified by UniProt accession
Q14181, 598 residues long.
MolForge cross-references it against 0 known binders and
300 disease associations.
Target properties
| Protein name | DNA polymerase alpha subunit B |
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| UniProt accession | Q14181 |
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| Gene | POLA2 |
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| Organism | Homo sapiens |
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| Length | 598 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (300)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.66
- non-small cell lung carcinoma · score 0.61
- acute lymphoblastic leukemia · score 0.60
- pancreatic carcinoma · score 0.59
- chronic lymphocytic leukemia · score 0.59
- ovarian carcinoma · score 0.57
- neoplasm · score 0.57
- breast carcinoma · score 0.57
- adult acute lymphoblastic leukemia · score 0.56
- leukemia · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14181-F1 | alphafold | PREDICTED | 84.77 | — |
Amino-acid sequence (598 residues)
MSASAQQLAE ELQIFGLDCE EALIEKLVEL CVQYGQNEEG MVGELIAFCT STHKVGLTSE ILNSFEHEFL SKRLSKARHS TCKDSGHAGA RDIVSIQELI EVEEEEEILL NSYTTPSKGS QKRAISTPET PLTKRSVSTR SPHQLLSPSS FSPSATPSQK YNSRSNRGEV VTSFGLAQGV SWSGRGGAGN ISLKVLGCPE ALTGSYKSMF QKLPDIREVL TCKIEELGSE LKEHYKIEAF TPLLAPAQEP VTLLGQIGCD SNGKLNNKSV ILEGDREHSS GAQIPVDLSE LKEYSLFPGQ VVIMEGINTT GRKLVATKLY EGVPLPFYQP TEEDADFEQS MVLVACGPYT TSDSITYDPL LDLIAVINHD RPDVCILFGP FLDAKHEQVE NCLLTSPFED IFKQCLRTII EGTRSSGSHL VFVPSLRDVH HEPVYPQPPF SYSDLSREDK KQVQFVSEPC SLSINGVIFG LTSTDLLFHL GAEEISSSSG TSDRFSRILK HILTQRSYYP LYPPQEDMAI DYESFYVYAQ LPVTPDVLII PSELRYFVKD VLGCVCVNPG RLTKGQVGGT FARLYLRRPA ADGAERQSPC IAVQVVRI
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