Double C2-like domain-containing protein alpha (DOC2A)

About Double C2-like domain-containing protein alpha

Double C2-like domain-containing protein alpha (DOC2A) is a protein from Homo sapiens identified by UniProt accession Q14183, 400 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Double C2-like domain-containing protein alpha
UniProt accession	Q14183
Gene	DOC2A
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
body height · score 0.30
lean body mass · score 0.27
sex hormone-binding globulin measurement · score 0.25
appendicular lean mass · score 0.25
body mass index · score 0.23
grip strength measurement · score 0.22
Diuretic use measurement · score 0.17
type 2 diabetes mellitus · score 0.16
diet measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14183-F1	alphafold	PREDICTED	77.99	—

Amino-acid sequence (400 residues)

MRGRRGDRMT INIQEHMAIN VCPGPIRPIR QISDYFPRGP GPEGGGGGGG EAPAHLVPLA LAPPAALLGA TTPEDGAEVD SYDSDDATAL GTLEFDLLYD RASCTLHCSI LRAKGLKPMD FNGLADPYVK LHLLPGACKA NKLKTKTQRN TLNPVWNEDL TYSGITDDDI THKVLRIAVC DEDKLSHNEF IGEIRVPLRR LKPSQKKHFN ICLERQVPLA SPSSMSAALR GISCYLKELE QAEQGQGLLE ERGRILLSLS YSSRRRGLLV GILRCAHLAA MDVNGYSDPY VKTYLRPDVD KKSKHKTCVK KKTLNPEFNE EFFYEIELST LATKTLEVTV WDYDIGKSND FIGGVSLGPG ARGEARKHWS DCLQQPDAAL ERWHTLTSEL PPAAGALSSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards