Double C2-like domain-containing protein beta (DOC2B)

About Double C2-like domain-containing protein beta

Double C2-like domain-containing protein beta (DOC2B) is a protein from Homo sapiens identified by UniProt accession Q14184, 412 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Double C2-like domain-containing protein beta
UniProt accession	Q14184
Gene	DOC2B
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

primary ovarian insufficiency · score 0.12
IGF-1 measurement · score 0.06
type 1 diabetes mellitus · score 0.04
neoplasm · score 0.03
ulcerative colitis · score 0.03
drug use measurement · score 0.02
glioblastoma multiforme · score 0.02
type 2 diabetes mellitus · score 0.02
calf circumference measurement · score 0.01
rosacea · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14184-F1	alphafold	PREDICTED	78.20	—

Amino-acid sequence (412 residues)

MTLRRRGEKA TISIQEHMAI DVCPGPIRPI KQISDYFPRF PRGLPPDAGP RAAAPPDAPA RPAVAGAGRR SPSDGAREDD EDVDQLFGAY GSSPGPSPGP SPARPPAKPP EDEPDADGYE SDDCTALGTL DFSLLYDQEN NALHCTITKA KGLKPMDHNG LADPYVKLHL LPGASKANKL RTKTLRNTLN PTWNETLTYY GITDEDMIRK TLRISVCDED KFRHNEFIGE TRVPLKKLKP NHTKTFSICL EKQLPVDKTE DKSLEERGRI LISLKYSSQK QGLLVGIVRC AHLAAMDANG YSDPYVKTYL RPDVDKKSKH KTAVKKKTLN PEFNEEFCYE IKHGDLAKKS LEVTVWDYDI GKSNDFIGGV VLGIHAKGER LKHWFDCLKN KDKRIERWHT LTSELPGAVL SD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards