Transcription factor Dp-2 (TFDP2)

About Transcription factor Dp-2

Transcription factor Dp-2 (TFDP2) is a protein from Homo sapiens identified by UniProt accession Q14188, 446 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Transcription factor Dp-2
UniProt accession	Q14188
Gene	TFDP2
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.48
mean corpuscular hemoglobin · score 0.39
creatinine measurement · score 0.35
urate measurement · score 0.34
glomerular filtration rate · score 0.33
endometrial cancer · score 0.29
head and neck squamous cell carcinoma · score 0.29
breast adenocarcinoma · score 0.29
lung adenocarcinoma · score 0.29
squamous cell lung carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14188-F1	alphafold	PREDICTED	65.18	—

Amino-acid sequence (446 residues)

MTAKNVGLTS TNAEVRGFID QNLSPTKGNI SFVAFPVSNT NSPTKILPKT LGPINVNVGP QMIISTPQRL TSSGSVLIGS PYTPAPAMVT QTHIAEATGW VPGDRKRARK FIDSDFSESK RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNNHLA ADSAYDQKNI RRRVYDALNV LMAMNIISKE KKEIKWIGLP TNSAQECQNL EIEKQRRIER IKQKRAQLQE LLLQQIAFKN LVQRNRQNEQ QNQGPPALNS TIQLPFIIIN TSRKTVIDCS ISSDKFEYLF NFDNTFEIHD DIEVLKRMGM SFGLESGKCS LEDLKLAKSL VPKALEGYIT DISTGPSWLN QGLLLNSTQS VSNLDLTTGA TLPQSSVNQG LCLDAEVALA TGQFLAPNSH QSSSAASHCS ESRGETPCSF NDEDEEDDEE DSSSPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards