Four and a half LIM domains protein 2 (FHL2)

About Four and a half LIM domains protein 2

Four and a half LIM domains protein 2 (FHL2) is a protein from Homo sapiens identified by UniProt accession Q14192, 279 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	Four and a half LIM domains protein 2
UniProt accession	Q14192
Gene	FHL2
Organism	Homo sapiens
Length	279 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (264)

Diseases linked to this target (Open Targets).

protein measurement · score 0.39
pulse pressure measurement · score 0.39
familial isolated dilated cardiomyopathy · score 0.37
body height · score 0.36
left ventricular structural measurement · score 0.34
PR interval · score 0.34
platelet count · score 0.31
BMI-adjusted hip circumference · score 0.28
skin cancer · score 0.27
appendicular lean mass · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14192-F1	alphafold	PREDICTED	92.08	—

Amino-acid sequence (279 residues)

MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC VPCYEKQHAM QCVQCKKPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards