About Dihydropyrimidinase-related protein 1
Dihydropyrimidinase-related protein 1 (CRMP1) is a protein
from Homo sapiens identified by UniProt accession
Q14194, 572 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Dihydropyrimidinase-related protein 1 |
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| UniProt accession | Q14194 |
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| Gene | CRMP1 |
|---|
| Organism | Homo sapiens |
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| Length | 572 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (88)
Diseases linked to this target (Open Targets).
- brain measurement · score 0.41
- cortical thickness · score 0.40
- neurodegenerative disease · score 0.34
- creatinine measurement · score 0.33
- neuroimaging measurement · score 0.32
- alkaline phosphatase measurement · score 0.31
- appendicular lean mass · score 0.28
- Abnormality of refraction · score 0.24
- electroencephalogram measurement · score 0.13
- mean corpuscular volume · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14194-F1 | alphafold | PREDICTED | 90.29 | — |
Amino-acid sequence (572 residues)
MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI VPGGVKTIEA NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG TTMIIDHVVP EPGSSLLTSF EKWHEAADTK SCCDYSLHVD ITSWYDGVRE ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ LYEAFTFLKG LGAVILVHAE NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI TIAGRINCPV YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL IPEGVNGIEE RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR IAVGSDADVV IWDPDKLKTI TAKSHKSAVE YNIFEGMECH GSPLVVISQG KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ RVKIRNKVFG LQGVSRGMYD GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS LSGAQIDDNN PRRTGHRIVA PPGGRSNITS LG
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