About Dihydropyrimidinase-related protein 3
Dihydropyrimidinase-related protein 3 (DPYSL3) is a protein
from Homo sapiens identified by UniProt accession
Q14195, 570 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Dihydropyrimidinase-related protein 3 |
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| UniProt accession | Q14195 |
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| Gene | DPYSL3 |
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| Organism | Homo sapiens |
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| Length | 570 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.40
- brain measurement · score 0.38
- neurodegenerative disease · score 0.37
- adolescent idiopathic scoliosis · score 0.34
- bone density · score 0.33
- urate measurement · score 0.33
- optic cup area measurement · score 0.33
- neuroimaging measurement · score 0.27
- autism · score 0.12
- axial length measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14195-F1 | alphafold | PREDICTED | 90.14 | — |
Amino-acid sequence (570 residues)
MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI VPGGVKTIEA NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG TTMIIDHVVP EPESSLTEAY EKWREWADGK SCCDYALHVD ITHWNDSVKQ EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE LYEIFTCLGE LGAIAQVHAE NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI TIASQTNCPL YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA IPEGTNGVEE RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR ISVGSDSDLV IWDPDAVKIV SAKNHQSAAE YNIFEGMELR GAPLVVICQG KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK RIKARRKMAD LHAVPRGMYD GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL SGTQVDEGVR SASKRIVAPP GGRSNITSLS
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