Large ribosomal subunit protein mL62 (MRPL58)

About Large ribosomal subunit protein mL62

Large ribosomal subunit protein mL62 (MRPL58) is a protein from Homo sapiens identified by UniProt accession Q14197, 206 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Large ribosomal subunit protein mL62
UniProt accession	Q14197
Gene	MRPL58
Organism	Homo sapiens
Length	206 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

small vessel stroke · score 0.12
Alzheimer disease · score 0.12
infect · score 0.05
infection · score 0.05
Blackfan-Diamond anemia · score 0.05
glioblastoma multiforme · score 0.05
osteosarcoma · score 0.05
primary familial polycythemia due to EPO receptor mutation · score 0.05
alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14197-F1	alphafold	PREDICTED	84.44	—

Amino-acid sequence (206 residues)

MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGGQ NVNKVNSKAE VRFHLATAEW IAEPVRQKIA ITHKNKINRL GELILTSESS RYQFRNLADC LQKIRDMITE ASQTPKEPTK EDVKLHRIRI ENMNRERLRQ KRIHSAVKTS RRVDMD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards