Transcription factor E2F2 (E2F2)

About Transcription factor E2F2

Transcription factor E2F2 (E2F2) is a protein from Homo sapiens identified by UniProt accession Q14209, 437 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.

Target properties

Protein name	Transcription factor E2F2
UniProt accession	Q14209
Gene	E2F2
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (263)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.46
Red cell distribution width · score 0.45
eosinophil count · score 0.45
mean corpuscular hemoglobin · score 0.44
leukocyte count · score 0.42
mean corpuscular hemoglobin concentration · score 0.42
erythrocyte count · score 0.40
reticulocyte count · score 0.40
neutrophil count · score 0.40
neurodegenerative disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14209-F1	alphafold	PREDICTED	63.13	—

Amino-acid sequence (437 residues)

MLQGPRALAS AAGQTPKVVP AMSPTELWPS GLSSPQLCPA TATYYTPLYP QTAPPAAAPG TCLDATPHGP EGQVVRCLPA GRLPAKRKLD LEGIGRPVVP EFPTPKGKCI RVDGLPSPKT PKSPGEKTRY DTSLGLLTKK FIYLLSESED GVLDLNWAAE VLDVQKRRIY DITNVLEGIQ LIRKKAKNNI QWVGRGMFED PTRPGKQQQL GQELKELMNT EQALDQLIQS CSLSFKHLTE DKANKRLAYV TYQDIRAVGN FKEQTVIAVK APPQTRLEVP DRTEDNLQIY LKSTQGPIEV YLCPEEVQEP DSPSEEPLPS TSTLCPSPDS AQPSSSTDPS IMEPTASSVP APAPTPQQAP PPPSLVPLEA TDSLLELPHP LLQQTEDQFL SPTLACSSPL ISFSPSLDQD DYLWGLEAGE GISDLFDSYD LGDLLIN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards