About Interleukin-27 subunit beta
Interleukin-27 subunit beta (EBI3) is a protein
from Homo sapiens identified by UniProt accession
Q14213, 229 residues long.
MolForge cross-references it against 0 known binders and
249 disease associations.
Target properties
| Protein name | Interleukin-27 subunit beta |
|---|
| UniProt accession | Q14213 |
|---|
| Gene | EBI3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 229 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (249)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- interleukin-27 measurement · score 0.27
- thyroid gland adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.21
- blood protein measurement · score 0.19
- protein measurement · score 0.12
- cutaneous melanoma · score 0.10
- neoplasm · score 0.10
- diffuse large B-cell lymphoma · score 0.09
- Burkitts lymphoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14213-F1 | alphafold | PREDICTED | 87.61 | — |
Amino-acid sequence (229 residues)
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK
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