About Translation initiation factor eIF2B subunit alpha
Translation initiation factor eIF2B subunit alpha (EIF2B1) is a protein
from Homo sapiens identified by UniProt accession
Q14232, 305 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Translation initiation factor eIF2B subunit alpha |
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| UniProt accession | Q14232 |
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| Gene | EIF2B1 |
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| Organism | Homo sapiens |
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| Length | 305 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- CACH syndrome · score 0.69
- leukoencephalopathy with vanishing white matter 1 · score 0.62
- leukoencephalopathy with vanishing white matter · score 0.57
- ovarioleukodystrophy · score 0.37
- juvenile or adult CACH syndrome · score 0.37
- congenital or early infantile CACH syndrome · score 0.37
- late infantile CACH syndrome · score 0.37
- neurodegenerative disease · score 0.29
- genetic disorder · score 0.19
- lymphocyte count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14232-F1 | alphafold | PREDICTED | 91.79 | — |
Amino-acid sequence (305 residues)
MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL
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