Eukaryotic initiation factor 4A-II (EIF4A2)

About Eukaryotic initiation factor 4A-II

Eukaryotic initiation factor 4A-II (EIF4A2) is a protein from Homo sapiens identified by UniProt accession Q14240, 407 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Eukaryotic initiation factor 4A-II
UniProt accession	Q14240
Gene	EIF4A2
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with hypotonia and speech delay, with or without seizures · score 0.60
Neurodevelopmental disorder · score 0.56
complex neurodevelopmental disorder · score 0.37
neurodegenerative disease · score 0.36
Neurodevelopmental delay · score 0.26
acute myeloid leukemia · score 0.20
esophageal squamous cell carcinoma · score 0.20
hepatocellular carcinoma · score 0.20
diffuse large B-cell lymphoma · score 0.20
non-small cell lung carcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14240-F1	alphafold	PREDICTED	86.36	—

Amino-acid sequence (407 residues)

MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards