P-selectin glycoprotein ligand 1 (SELPLG)

About P-selectin glycoprotein ligand 1

P-selectin glycoprotein ligand 1 (SELPLG) is a protein from Homo sapiens identified by UniProt accession Q14242, 412 residues long. MolForge cross-references it against 0 known binders and 478 disease associations.

Target properties

Protein name	P-selectin glycoprotein ligand 1
UniProt accession	Q14242
Gene	SELPLG
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (478)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.31
glioblastoma multiforme · score 0.19
breast adenocarcinoma · score 0.18
intraocular pressure measurement · score 0.17
optic disc size measurement · score 0.14
inflammatory bowel disease · score 0.13
reticulocyte count · score 0.12
reticulocyte measurement · score 0.11
neoplasm · score 0.11
low grade glioma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14242-F1	alphafold	PREDICTED	50.37	—

Amino-acid sequence (412 residues)

MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards