Src substrate cortactin (CTTN)

About Src substrate cortactin

Src substrate cortactin (CTTN) is a protein from Homo sapiens identified by UniProt accession Q14247, 550 residues long. MolForge cross-references it against 0 known binders and 322 disease associations.

Target properties

Protein name	Src substrate cortactin
UniProt accession	Q14247
Gene	CTTN
Organism	Homo sapiens
Length	550 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (322)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.33
glioblastoma multiforme · score 0.19
neoplasm · score 0.11
infection · score 0.09
infect · score 0.09
esophageal squamous cell carcinoma · score 0.09
chronic lymphocytic leukemia · score 0.09
non-small cell lung carcinoma · score 0.08
hepatocellular carcinoma · score 0.08
acute lymphoblastic leukemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14247-F1	alphafold	PREDICTED	62.46	—

Amino-acid sequence (550 residues)

MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG KTEKHESQRD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT DRQDKCALGW DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ DSAAVGFDYK EKLAKHESQQ DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI RANFENLAKE KEQEDRRKAE AERAQRMAKE RQEQEEARRK LEEQARAKTQ TPPVSPAPQP TEERLPSSPV YEDAASFKAE LSYRGPVSGT EPEPVYSMEA ADYREASSQQ GLAYATEAVY ESAEAPGHYP AEDSTYDEYE NDLGITAVAL YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL FPANYVELRQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards