Endonuclease G, mitochondrial (ENDOG)

About Endonuclease G, mitochondrial

Endonuclease G, mitochondrial (ENDOG) is a protein from Homo sapiens identified by UniProt accession Q14249, 297 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Endonuclease G, mitochondrial
UniProt accession	Q14249
Gene	ENDOG
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

serum metabolite measurement · score 0.28
high density lipoprotein cholesterol measurement · score 0.25
serum albumin measurement · score 0.23
BMI-adjusted waist-hip ratio · score 0.19
bilirubin measurement · score 0.19
BMI-adjusted waist circumference · score 0.19
blood metabolite measurement · score 0.15
triglyceride measurement · score 0.15
calcium measurement · score 0.14
allergic disease · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14249-F1	alphafold	PREDICTED	84.34	—

Amino-acid sequence (297 residues)

MRALRAGLTL ASGAGLGAVV EGWRRRREDA RAAPGLLGRL PVLPVAAAAE LPPVPGGPRG PGELAKYGLP GLAQLKSRES YVLCYDPRTR GALWVVEQLR PERLRGDGDR RECDFREDDS VHAYHRATNA DYRGSGFDRG HLAAAANHRW SQKAMDDTFY LSNVAPQVPH LNQNAWNNLE KYSRSLTRSY QNVYVCTGPL FLPRTEADGK SYVKYQVIGK NHVAVPTHFF KVLILEAAGG QIELRTYVMP NAPVDEAIPL ERFLVPIESI ERASGLLFVP NILARAGSLK AITAGSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards