Flotillin-2 (FLOT2)

About Flotillin-2

Flotillin-2 (FLOT2) is a protein from Homo sapiens identified by UniProt accession Q14254, 428 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Flotillin-2
UniProt accession	Q14254
Gene	FLOT2
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.22
lung adenocarcinoma · score 0.18
cognitive function measurement · score 0.17
serum gamma-glutamyl transferase measurement · score 0.16
mean reticulocyte volume · score 0.11
calf circumference measurement · score 0.09
HbA1c measurement · score 0.09
breast cancer · score 0.08
neoplasm · score 0.08
gestational diabetes · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14254-F1	alphafold	PREDICTED	82.03	—

Amino-acid sequence (428 residues)

MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI KKATGVQV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards