About Reticulocalbin-2
Reticulocalbin-2 (RCN2) is a protein
from Homo sapiens identified by UniProt accession
Q14257, 317 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Reticulocalbin-2 |
|---|
| UniProt accession | Q14257 |
|---|
| Gene | RCN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 317 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.22
- mean platelet volume · score 0.20
- serum urea measurement · score 0.15
- cystatin C measurement · score 0.13
- urate measurement · score 0.13
- glomerular filtration rate · score 0.13
- creatinine measurement · score 0.13
- neutrophil count · score 0.10
- Arrhythmogenic right ventricular dysplasia · score 0.07
- brain measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14257-F1 | alphafold | PREDICTED | 78.03 | — |
Amino-acid sequence (317 residues)
MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED VDEYVKLGHE EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ EAKQQFVEYD KNSDDTVTWD EYNIQMYDRV IDFDENTALD DAEEESFRKL HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP EEVDYMTEFV IQEALEEHDK NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD KDNDGRLDPQ ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA TDYGRQLHDD YFYHDEL
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