About Endogenous retrovirus group 3 member 1 Env polyprotein
Endogenous retrovirus group 3 member 1 Env polyprotein (ERV3-1) is a protein
from Homo sapiens identified by UniProt accession
Q14264, 604 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Endogenous retrovirus group 3 member 1 Env polyprotein |
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| UniProt accession | Q14264 |
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| Gene | ERV3-1 |
|---|
| Organism | Homo sapiens |
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| Length | 604 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- cancer · score 0.05
- neoplasm · score 0.04
- acute myeloid leukemia · score 0.02
- Rheumatoid arthritis · score 0.02
- melanoma · score 0.02
- acute lymphoblastic leukemia · score 0.02
- infect · score 0.01
- infection · score 0.01
- Obesity · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14264-F1 | alphafold | PREDICTED | 66.23 | — |
Amino-acid sequence (604 residues)
MLGMNMLLIT LFLLLPLSML KGEPWEGCLH CTHTTWSGNI MTKTLLYHTY YECAGTCLGT CTHNQTTYSV CDPGRGQPYV CYDPKSSPGT WFEIHVGSKE GDLLNQTKVF PSGKDVVSLY FDVCQIVSMG SLFPVIFSSM EYYSSCHKNR YAHPACSTDS PVTTCWDCTT WSTNQQSLGP IMLTKIPLEP DCKTSTCNSV NLTILEPDQP IWTTGLKAPL GARVSGEEIG PGAYVYLYII KKTRTRSTQQ FRVFESFYEH VNQKLPEPPP LASNLFAQLA ENIASSLHVA SCYVCGGMNM GDQWPWEARE LMPQDNFTLT ASSLEPAPSS QSIWFLKTSI IGKFCIARWG KAFTDPVGEL TCLGQQYYNE TLGKTLWRGK SNNSESPHPS PFSRFPSLNH SWYQLEAPNT WQAPSGLYWI CGPQAYRQLP AKWSGACVLG TIRPSFFLMP LKQGEALGYP IYDETKRKSK RGITIGDWKD NEWPPERIIQ YYGPATWAED GMWGYRTPVY MLNRIIRLQA VLEIITNETA GALNLLAQQA TKMRNVIYQN RLALDYLLAQ EEGVCGKFNL TNCCLELDDE GKVIKEITAK IQKLAHIPVQ TWKG
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