Fas-activated serine/threonine kinase (FASTK)

About Fas-activated serine/threonine kinase

Fas-activated serine/threonine kinase (FASTK) is a protein from Homo sapiens identified by UniProt accession Q14296, 549 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Fas-activated serine/threonine kinase
UniProt accession	Q14296
Gene	FASTK
Organism	Homo sapiens
Length	549 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
Alzheimer disease · score 0.37
lysosomal storage disease · score 0.37
Parkinson disease · score 0.37
multiple sclerosis · score 0.37
IGF-1 measurement · score 0.08
cancer · score 0.08
MODY · score 0.08
creatinine measurement · score 0.07
cortical thickness · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14296-F1	alphafold	PREDICTED	73.78	—

Amino-acid sequence (549 residues)

MRRPRGEPGP RAPRPTEGAT CAGPGESWSP SPNSMLRVLL SAQTSPARLS GLLLIPPVQP CCLGPSKWGD RPVGGGPSAG PVQGLQRLLE QAKSPGELLR WLGQNPSKVR AHHYSVALRR LGQLLGSRPR PPPVEQVTLQ DLSQLIIRNC PSFDIHTIHV CLHLAVLLGF PSDGPLVCAL EQERRLRLPP KPPPPLQPLL RGGQGLEAAL SCPRFLRYPR QHLISSLAEA RPEELTPHVM VLLAQHLARH RLREPQLLEA IAHFLVVQET QLSSKVVQKL VLPFGRLNYL PLEQQFMPCL ERILAREAGV APLATVNILM SLCQLRCLPF RALHFVFSPG FINYISGTPH ALIVRRYLSL LDTAVELELP GYRGPRLPRR QQVPIFPQPL ITDRARCKYS HKDIVAEGLR QLLGEEKYRQ DLTVPPGYCT DFLLCASSSG AVLPVRTQDP FLPYPPRSCP QGQAASSATT RDPAQRVVLV LRERWHFCRD GRVLLGSRAL RERHLGLMGY QLLPLPFEEL ESQRGLPQLK SYLRQKLQAL GLRWGPEGG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards