Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

About Peptidyl-prolyl cis-trans isomerase FKBP8

Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) is a protein from Homo sapiens identified by UniProt accession Q14318, 412 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase FKBP8
UniProt accession	Q14318
Gene	FKBP8
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.23
ovarian cancer · score 0.23
breast adenocarcinoma · score 0.23
spina bifida · score 0.19
potassium measurement · score 0.18
esophageal cancer · score 0.10
glioblastoma · score 0.05
microcephaly-cervical spine fusion anomalies syndrome · score 0.04
Microcephaly - cervical spine fusion anomalies · score 0.04
Hyperlipidemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14318-F1	alphafold	PREDICTED	80.63	—

Amino-acid sequence (412 residues)

MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards