About Frizzled-2
Frizzled-2 (FZD2) is a protein
from Homo sapiens identified by UniProt accession
Q14332, 565 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Frizzled-2 |
|---|
| UniProt accession | Q14332 |
|---|
| Gene | FZD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 565 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- autosomal dominant omodysplasia · score 0.72
- Robinow syndrome · score 0.62
- autosomal dominant Robinow syndrome · score 0.60
- omodysplasia · score 0.40
- Short stature · score 0.29
- endometrial cancer · score 0.25
- hip bone size · score 0.20
- white matter microstructure measurement · score 0.18
- keratoconus · score 0.11
- breast cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14332-F1 | alphafold | PREDICTED | 83.43 | — |
Amino-acid sequence (565 residues)
MRPRSALPRL LLPLLLLPAA GPAQFHGEKG ISIPDHGFCQ PISIPLCTDI AYNQTIMPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLEQAIPPC RSICERARQG CEALMNKFGF QWPERLRCEH FPRHGAEQIC VGQNHSEDGA PALLTTAPPP GLQPGAGGTP GGPGGGGAPP RYATLEHPFH CPRVLKVPSY LSYKFLGERD CAAPCEPARP DGSMFFSQEE TRFARLWILT WSVLCCASTF FTVTTYLVDM QRFRYPERPI IFLSGCYTMV SVAYIAGFVL QERVVCNERF SEDGYRTVVQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AVKTITILAM GQIDGDLLSG VCFVGLNSLD PLRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLERLMV RIGVFSVLYT VPATIVIACY FYEQAFREHW ERSWVSQHCK SLAIPCPAHY TPRMSPDFTV YMIKYLMTLI VGITSGFWIW SGKTLHSWRK FYTRLTNSRH GETTV
Explore Frizzled-2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets