About Guanidinoacetate N-methyltransferase
Guanidinoacetate N-methyltransferase (GAMT) is a protein
from Homo sapiens identified by UniProt accession
Q14353, 236 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Guanidinoacetate N-methyltransferase |
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| UniProt accession | Q14353 |
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| Gene | GAMT |
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| Organism | Homo sapiens |
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| Length | 236 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- guanidinoacetate methyltransferase deficiency · score 0.86
- cerebral creatine deficiency syndrome · score 0.58
- genetic disorder · score 0.53
- Intellectual disability · score 0.40
- Seizure · score 0.40
- Abnormality of the nervous system · score 0.34
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.06
- ichthyosis-intellectual disability-dwarfism-renal impairment syndrome · score 0.03
- ring chromosome Y · score 0.03
- pachyonychia congenita · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14353-F1 | alphafold | PREDICTED | 96.45 | — |
Amino-acid sequence (236 residues)
MSAPSATPIF APGENCSPAW GAAPAAYDAA DTHLRILGKP VMERWETPYM HALAAAASSK GGRVLEVGFG MAIAASKVQE APIDEHWIIE CNDGVFQRLR DWAPRQTHKV IPLKGLWEDV APTLPDGHFD GILYDTYPLS EETWHTHQFN FIKNHAFRLL KPGGVLTYCN LTSWGELMKS KYSDITIMFE ETQVPALLEA GFRRENIRTE VMALVPPADC RYYAFPQMIT PLVTKG
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