UDP-glucose 4-epimerase (GALE)

About UDP-glucose 4-epimerase

UDP-glucose 4-epimerase (GALE) is a protein from Homo sapiens identified by UniProt accession Q14376, 348 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	UDP-glucose 4-epimerase
UniProt accession	Q14376
Gene	GALE
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (90)

Diseases linked to this target (Open Targets).

galactose epimerase deficiency · score 0.84
Intellectual disability · score 0.46
genetic disorder · score 0.41
galactosemia · score 0.37
erythrocyte galactose epimerase deficiency · score 0.37
generalized galactose epimerase deficiency · score 0.37
neuroinflammatory disorder · score 0.24
reticulocyte count · score 0.12
reticulocyte measurement · score 0.07
psychotic symptoms · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14376-F1	alphafold	PREDICTED	97.08	—

Amino-acid sequence (348 residues)

MAEKVLVTGG AGYIGSHTVL ELLEAGYLPV VIDNFHNAFR GGGSLPESLR RVQELTGRSV EFEEMDILDQ GALQRLFKKY SFMAVIHFAG LKAVGESVQK PLDYYRVNLT GTIQLLEIMK AHGVKNLVFS SSATVYGNPQ YLPLDEAHPT GGCTNPYGKS KFFIEEMIRD LCQADKTWNA VLLRYFNPTG AHASGCIGED PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD YIHVVDLAKG HIAALRKLKE QCGCRIYNLG TGTGYSVLQM VQAMEKASGK KIPYKVVARR EGDVAACYAN PSLAQEELGW TAALGLDRMC EDLWRWQKQN PSGFGTQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards