About Transforming growth factor beta activator LRRC32
Transforming growth factor beta activator LRRC32 (LRRC32) is a protein
from Homo sapiens identified by UniProt accession
Q14392, 662 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Transforming growth factor beta activator LRRC32 |
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| UniProt accession | Q14392 |
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| Gene | LRRC32 |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (151)
Diseases linked to this target (Open Targets).
- cleft palate, proliferative retinopathy, and developmental delay · score 0.52
- eosinophil count · score 0.35
- atopic eczema · score 0.35
- eosinophil percentage of leukocytes · score 0.33
- allergic disease · score 0.33
- asthma · score 0.32
- childhood onset asthma · score 0.31
- Herpes Zoster · score 0.31
- allergic rhinitis · score 0.30
- inflammatory bowel disease · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14392-F1 | alphafold | PREDICTED | 86.08 | — |
Amino-acid sequence (662 residues)
MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD TETLDLSGNQ LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE HLSLAHNRLA MATALSAGGL GPLPRVTSLD LSGNSLYSGL LERLLGEAPS LHTLSLAENS LTRLTRHTFR DMPALEQLDL HSNVLMDIED GAFEGLPRLT HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ AEFQLTWLDL RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC LRTFEARRLG SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD LPPYTFANLA SLQRLNLQGN RVSPCGGPDE PGPSGCVAFS GITSLRSLSL VDNEIELLRA GAFLHTPLTE LDLSSNPGLE VATGALGGLE ASLEVLALQG NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV LDLRNNSFSL LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC VRRQKFNQQY KA
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