About Growth arrest-specific protein 6
Growth arrest-specific protein 6 (GAS6) is a protein
from Homo sapiens identified by UniProt accession
Q14393, 678 residues long.
MolForge cross-references it against 0 known binders and
455 disease associations.
Target properties
| Protein name | Growth arrest-specific protein 6 |
|---|
| UniProt accession | Q14393 |
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| Gene | GAS6 |
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| Organism | Homo sapiens |
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| Length | 678 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (455)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.50
- Red cell distribution width · score 0.49
- low density lipoprotein cholesterol measurement · score 0.49
- HbA1c measurement · score 0.48
- erythrocyte count · score 0.48
- hemoglobin measurement · score 0.47
- hematocrit · score 0.46
- alkaline phosphatase measurement · score 0.46
- total cholesterol measurement · score 0.45
- aspartate aminotransferase measurement · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14393-F1 | alphafold | PREDICTED | 85.57 | — |
Amino-acid sequence (678 residues)
MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF QVFEEAKQGH LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG SPYTKNSGFA TCVQNLPDQC TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL RAGRLELQLR YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV MKIAVAGDLF QPERGLYHLN LTVGGIPFHE KDLVQPINPR LDGCMRSWNW LNGEDTTIQE TVKVNTRMQC FSVTERGSFY PGSGFAFYSL DYMRTPLDVG TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV DYHSTKKLKK QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR RLLDLDEAAY KHSDITAHSC PPVEPAAA
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