About Chorionic somatomammotropin hormone-like 1
Chorionic somatomammotropin hormone-like 1 (CSHL1) is a protein
from Homo sapiens identified by UniProt accession
Q14406, 222 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Chorionic somatomammotropin hormone-like 1 |
|---|
| UniProt accession | Q14406 |
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| Gene | CSHL1 |
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| Organism | Homo sapiens |
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| Length | 222 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.25
- lymphocyte count · score 0.21
- body height · score 0.20
- BMI-adjusted hip circumference · score 0.18
- appendicular lean mass · score 0.15
- brain volume measurement · score 0.14
- neuroimaging measurement · score 0.14
- PR interval · score 0.09
- Pituicytoma · score 0.06
- growth hormone-secreting pituitary adenoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14406-F1 | alphafold | PREDICTED | 75.60 | — |
Amino-acid sequence (222 residues)
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD MDKVETFLRM VQCRSVEGSC GF
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