About Glycerol kinase 3
Glycerol kinase 3 (GK3) is a protein
from Homo sapiens identified by UniProt accession
Q14409, 553 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Glycerol kinase 3 |
|---|
| UniProt accession | Q14409 |
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| Gene | GK3 |
|---|
| Organism | Homo sapiens |
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| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- intelligence · score 0.08
- cognitive function measurement · score 0.08
- vitamin D measurement · score 0.06
- glycogen storage disease VI · score 0.05
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.05
- neuroticism measurement · score 0.05
- MODY · score 0.04
- glycogen storage disease III · score 0.04
- glycogen storage disease due to liver phosphorylase kinase deficiency · score 0.04
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14409-F1 | alphafold | PREDICTED | 92.25 | — |
Amino-acid sequence (553 residues)
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE GWVEQDPKEI LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY GLMKAGALEG VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK EVGTSYGCYF VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPL MPETTALGAA MAAGAAEGVD VWSLEPEDLS AVTMERFEPQ INAEESEIRY STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM AMLIGARYIS GIP
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