Glycerol kinase 2 (GK2)

About Glycerol kinase 2

Glycerol kinase 2 (GK2) is a protein from Homo sapiens identified by UniProt accession Q14410, 553 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Glycerol kinase 2
UniProt accession	Q14410
Gene	GK2
Organism	Homo sapiens
Length	553 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

Myopia · score 0.32
refractive error · score 0.31
age at onset · score 0.28
smoking status measurement · score 0.24
smoking behavior · score 0.24
Abnormality of refraction · score 0.20
protein measurement · score 0.16
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.11
spermatogenic failure 10 · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14410-F1	alphafold	PREDICTED	91.97	—

Amino-acid sequence (553 residues)

MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS GVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards