About Polypeptide N-acetylgalactosaminyltransferase 3
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) is a protein
from Homo sapiens identified by UniProt accession
Q14435, 633 residues long.
MolForge cross-references it against 0 known binders and
288 disease associations.
Target properties
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 3 |
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| UniProt accession | Q14435 |
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| Gene | GALNT3 |
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| Organism | Homo sapiens |
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| Length | 633 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (288)
Diseases linked to this target (Open Targets).
- familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome · score 0.79
- bone density · score 0.46
- Hyperphosphatemia · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.37
- alkaline phosphatase measurement · score 0.36
- cognitive function measurement · score 0.34
- spine bone mineral density · score 0.30
- femoral neck bone mineral density · score 0.30
- lean body mass · score 0.30
- type 2 diabetes mellitus · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14435-F1 | alphafold | PREDICTED | 89.82 | — |
Amino-acid sequence (633 residues)
MAHLKRLVKL HIKRHYHKKF WKLGAVIFFF IIVLVLMQRE VSVQYSKEES RMERNMKNKN KMLDLMLEAV NNIKDAMPKM QIGAPVRQNI DAGERPCLQG YYTAAELKPV LDRPPQDSNA PGASGKAFKT TNLSVEEQKE KERGEAKHCF NAFASDRISL HRDLGPDTRP PECIEQKFKR CPPLPTTSVI IVFHNEAWST LLRTVHSVLY SSPAILLKEI ILVDDASVDE YLHDKLDEYV KQFSIVKIVR QRERKGLITA RLLGATVATA ETLTFLDAHC ECFYGWLEPL LARIAENYTA VVSPDIASID LNTFEFNKPS PYGSNHNRGN FDWSLSFGWE SLPDHEKQRR KDETYPIKTP TFAGGLFSIS KEYFEYIGSY DEEMEIWGGE NIEMSFRVWQ CGGQLEIMPC SVVGHVFRSK SPHSFPKGTQ VIARNQVRLA EVWMDEYKEI FYRRNTDAAK IVKQKAFGDL SKRFEIKHRL QCKNFTWYLN NIYPEVYVPD LNPVISGYIK SVGQPLCLDV GENNQGGKPL IMYTCHGLGG NQYFEYSAQH EIRHNIQKEL CLHAAQGLVQ LKACTYKGHK TVVTGEQIWE IQKDQLLYNP FLKMCLSANG EHPSLVSCNP SDPLQKWILS QND
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