G-protein coupled receptor 176 (GPR176)

About G-protein coupled receptor 176

G-protein coupled receptor 176 (GPR176) is a protein from Homo sapiens identified by UniProt accession Q14439, 515 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	G-protein coupled receptor 176
UniProt accession	Q14439
Gene	GPR176
Organism	Homo sapiens
Length	515 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

body height · score 0.32
gut microbiome measurement · score 0.30
gonorrhea · score 0.09
gastric adenocarcinoma · score 0.08
neoplasm · score 0.07
breast cancer · score 0.07
cortical thickness · score 0.06
congenital secretory chloride diarrhea 1 · score 0.05
brain volume measurement · score 0.05
brain measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14439-F1	alphafold	PREDICTED	66.46	—

Amino-acid sequence (515 residues)

MGHNGSWISP NASEPHNASG AEAAGVNRSA LGEFGEAQLY RQFTTTVQVV IFIGSLLGNF MVLWSTCRTT VFKSVTNRFI KNLACSGICA SLVCVPFDII LSTSPHCCWW IYTMLFCKVV KFLHKVFCSV TILSFPAIAL DRYYSVLYPL ERKISDAKSR ELVMYIWAHA VVASVPVFAV TNVADIYATS TCTEVWSNSL GHLVYVLVYN ITTVIVPVVV VFLFLILIRR ALSASQKKKV IIAALRTPQN TISIPYASQR EAELHATLLS MVMVFILCSV PYATLVVYQT VLNVPDTSVF LLLTAVWLPK VSLLANPVLF LTVNKSVRKC LIGTLVQLHH RYSRRNVVST GSGMAEASLE PSIRSGSQLL EMFHIGQQQI FKPTEDEEES EAKYIGSADF QAKEIFSTCL EGEQGPQFAP SAPPLSTVDS VSQVAPAAPV EPETFPDKYS LQFGFGPFEL PPQWLSETRN SKKRLLPPLG NTPEELIQTK VPKVGRVERK MSRNNKVSIF PKVDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards