Growth factor receptor-bound protein 14 (GRB14)

About Growth factor receptor-bound protein 14

Growth factor receptor-bound protein 14 (GRB14) is a protein from Homo sapiens identified by UniProt accession Q14449, 540 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Growth factor receptor-bound protein 14
UniProt accession	Q14449
Gene	GRB14
Organism	Homo sapiens
Length	540 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.41
body mass index · score 0.40
triglyceride measurement · score 0.39
body fat percentage · score 0.39
fat body mass · score 0.39
adolescent idiopathic scoliosis · score 0.37
body weight · score 0.34
neurodegenerative disease · score 0.34
hip circumference · score 0.31
diastolic blood pressure · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14449-F1	alphafold	PREDICTED	76.67	—

Amino-acid sequence (540 residues)

MTTSLQDGQS AASRAAARDS PLAAQVCGAA QGRGDAHDLA PAPWLHARAL LPLPDGTRGC AADRRKKKDL DVPEMPSIPN PFPELCCSPF TSVLSADLFP KANSRKKQVI KVYSEDETSR ALDVPSDITA RDVCQLLILK NHYIDDHSWT LFEHLPHIGV ERTIEDHELV IEVLSNWGIE EENKLYFRKN YAKYEFFKNP MYFFPEHMVS FATETNGEIS PTQILQMFLS SSTYPEIHGF LHAKEQGKKS WKKIYFFLRR SGLYFSTKGT SKEPRHLQFF SEFGNSDIYV SLAGKKKHGA PTNYGFCFKP NKAGGPRDLK MLCAEEEQSR TCWVTAIRLL KYGMQLYQNY MHPYQGRSGC SSQSISPMRS ISENSLVAMD FSGQKSRVIE NPTEALSVAV EEGLAWRKKG CLRLGTHGSP TASSQSSATN MAIHRSQPWF HHKISRDEAQ RLIIQQGLVD GVFLVRDSQS NPKTFVLSMS HGQKIKHFQI IPVEDDGEMF HTLDDGHTRF TDLIQLVEFY QLNKGVLPCK LKHYCARIAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards