About Growth factor receptor-bound protein 7
Growth factor receptor-bound protein 7 (GRB7) is a protein
from Homo sapiens identified by UniProt accession
Q14451, 532 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Growth factor receptor-bound protein 7 |
|---|
| UniProt accession | Q14451 |
|---|
| Gene | GRB7 |
|---|
| Organism | Homo sapiens |
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| Length | 532 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (146)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.28
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.25
- endometrial cancer · score 0.24
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- creatinine measurement · score 0.19
- cutaneous melanoma · score 0.18
- gastric adenocarcinoma · score 0.14
- Myopia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14451-F1 | alphafold | PREDICTED | 77.97 | — |
Amino-acid sequence (532 residues)
MELDLSPPHL SSSPEDLCPA PGTPPGTPRP PDTPLPEEVK RSQPLLIPTT GRKLREEERR ATSLPSIPNP FPELCSPPSQ SPILGGPSSA RGLLPRDASR PHVVKVYSED GACRSVEVAA GATARHVCEM LVQRAHALSD ETWGLVECHP HLALERGLED HESVVEVQAA WPVGGDSRFV FRKNFAKYEL FKSSPHSLFP EKMVSSCLDA HTGISHEDLI QNFLNAGSFP EIQGFLQLRG SGRKLWKRFF CFLRRSGLYY STKGTSKDPR HLQYVADVNE SNVYVVTQGR KLYGMPTDFG FCVKPNKLRN GHKGLRIFCS EDEQSRTCWL AAFRLFKYGV QLYKNYQQAQ SRHLHPSCLG SPPLRSASDN TLVAMDFSGH AGRVIENPRE ALSVALEEAQ AWRKKTNHRL SLPMPASGTS LSAAIHRTQL WFHGRISREE SQRLIGQQGL VDGLFLVRES QRNPQGFVLS LCHLQKVKHY LILPSEEEGR LYFSMDDGQT RFTDLLQLVE FHQLNRGILP CLLRHCCTRV AL
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