Beclin-1 (BECN1)

About Beclin-1

Beclin-1 (BECN1) is a protein from Homo sapiens identified by UniProt accession Q14457, 450 residues long. MolForge cross-references it against 0 known binders and 700 disease associations.

Target properties

Protein name	Beclin-1
UniProt accession	Q14457
Gene	BECN1
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (700)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
COVID-19 · score 0.48
severe acute respiratory syndrome · score 0.37
lysosomal storage disease · score 0.28
ovarian cancer · score 0.23
neoplasm · score 0.12
hepatocellular carcinoma · score 0.11
breast cancer · score 0.11
cancer · score 0.11
esophageal squamous cell carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14457-F1	alphafold	PREDICTED	76.59	—

Amino-acid sequence (450 residues)

MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN SEEQWTKALK FMLTNLKWGL AWVSSQFYNK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards