About Transcription factor HES-1
Transcription factor HES-1 (HES1) is a protein
from Homo sapiens identified by UniProt accession
Q14469, 280 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Transcription factor HES-1 |
|---|
| UniProt accession | Q14469 |
|---|
| Gene | HES1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (143)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- hemoglobin measurement · score 0.38
- hematocrit · score 0.37
- cortical surface area measurement · score 0.36
- erythrocyte count · score 0.35
- creatinine measurement · score 0.34
- adolescent idiopathic scoliosis · score 0.33
- glomerular filtration rate · score 0.33
- brain measurement · score 0.30
- blood urea nitrogen measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14469-F1 | alphafold | PREDICTED | 68.62 | — |
Amino-acid sequence (280 residues)
MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQPH PALQAPPPPP PGPGGPQHAP FAPPPPLVPI PGGAAPPPGG APCKLGSQAG EAAKVFGGFQ VVPAPDGQFA FLIPNGAFAH SGPVIPVYTS NSGTSVGPNA VSPSSGPSLT ADSMWRPWRN
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