About Endoplasmic reticulum membrane sensor NFE2L1
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) is a protein
from Homo sapiens identified by UniProt accession
Q14494, 772 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Endoplasmic reticulum membrane sensor NFE2L1 |
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| UniProt accession | Q14494 |
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| Gene | NFE2L1 |
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| Organism | Homo sapiens |
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| Length | 772 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (192)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.23
- body mass index · score 0.15
- cystatin C measurement · score 0.15
- sex hormone-binding globulin measurement · score 0.14
- high density lipoprotein cholesterol measurement · score 0.14
- leukocyte count · score 0.13
- triglyceride measurement · score 0.13
- heel bone mineral density · score 0.13
- FEV/FVC ratio · score 0.13
- myeloid white cell count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14494-F1 | alphafold | PREDICTED | 54.82 | — |
Amino-acid sequence (772 residues)
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE QDVEKELRDG GEQDTWAGEG AEALARNLLV DGETGESFPA QVPSGEDQTA LSLEECLRLL EATCPFGENA EFPADISSIT EAVPSESEPP ALQNNLLSPL LTGTESPFDL EQQWQDLMSI MEMQAMEVNT SASEILYSAP PGDPLSTNYS LAPNTPINQN VSLHQASLGG CSQDFLLFSP EVESLPVASS STLLPLAPSN STSLNSTFGS TNLTGLFFPP QLNGTANDTA GPELPDPLGG LLDEAMLDEI SLMDLAIEEG FNPVQASQLE EEFDSDSGLS LDSSHSPSSL SSSEGSSSSS SSSSSSSSSA SSSASSSFSE EGAVGYSSDS ETLDLEEAEG AVGYQPEYSK FCRMSYQDPA QLSCLPYLEH VGHNHTYNMA PSALDSADLP PPSALKKGSK EKQADFLDKQ MSRDEHRARA MKIPFTNDKI INLPVEEFNE LLSKYQLSEA QLSLIRDIRR RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ RDKARLLREK VEFLRSLRQM KQKVQSLYQE VFGRLRDENG RPYSPSQYAL QYAGDGSVLL IPRTMADQQA RRQERKPKDR RK
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