RNA-binding protein 39 (RBM39)

About RNA-binding protein 39

RNA-binding protein 39 (RBM39) is a protein from Homo sapiens identified by UniProt accession Q14498, 530 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	RNA-binding protein 39
UniProt accession	Q14498
Gene	RBM39
Organism	Homo sapiens
Length	530 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
endometrial cancer · score 0.21
colorectal carcinoma · score 0.15
intelligence · score 0.13
waist circumference · score 0.10
neoplasm · score 0.09
hepatocellular carcinoma · score 0.09
cancer · score 0.09
mean platelet volume · score 0.08
neuroblastoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14498-F1	alphafold	PREDICTED	66.79	—

Amino-acid sequence (530 residues)

MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS KSKERKRSRD RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYS GPKFNSAIRG KIGLPHSIKL SRRRSRSKSP FRKDKSPVRE PIDNLTPEER DARTVFCMQL AARIRPRDLE EFFSTVGKVR DVRMISDRNS RRSKGIAYVE FVDVSSVPLA IGLTGQRVLG VPIIVQASQA EKNRAAAMAN NLQKGSAGPM RLYVGSLHFN ITEDMLRGIF EPFGRIESIQ LMMDSETGRS KGYGFITFSD SECAKKALEQ LNGFELAGRP MKVGHVTERT DASSASSFLD SDELERTGID LGTTGRLQLM ARLAEGTGLQ IPPAAQQALQ MSGSLAFGAV AEFSFVIDLQ TRLSQQTEAS ALAAAASVQP LATQCFQLSN MFNPQTEEEV GWDTEIKDDV IEECNKHGGV IHIYVDKNSA QGNVYVKCPS IAAAIAAVNA LHGRWFAGKM ITAAYVPLPT YHNLFPDSMT ATQLLVPSRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards